Tofranil® contains the active ingredient imipramine hydrochloride and belongs to a group of medicines known as tricyclic antidepressants used in the treatment of depressive mood disorders.

Tofranil® is used in the treatment of various forms of depression in adults, occurring during psychiatric (depressive phase of manic depressive psychosis, masked depression, neurotic depression, depression in schizophrenic psychosis), neurological and other diseases [late-onset (involutional) depression, severe depressions in neurological diseases and other organic conditions] or depression due to a triggering event (reactive depression).

Adults: In outpatients: Treatment is started with 25 mg 1-3 times daily and the daily dosage is gradually increased to 150-200 mg. This dosage should be reached by the end of the first week and should be used until significant improvement is achieved. The maintenance dose, which should be determined individually for each patient by carefully decreasing the dose, is usually between 50-100 mg per day.
In patients receiving treatment in hospital: Treatment is started with 25 mg three times daily. The dosage is increased by 25 mg each day until the daily dose reaches 200 mg, and this dosage is continued until the patient's condition improves. In severe cases, 300 mg per day may be given in three divided doses. The maintenance dose should be determined individually for each patient (usually 100 mg per day).

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